The University was established in 1995 vide Sikkim Manipal University of Health, Medical and Technological Sciences Act (Act No. 9 of 1995). SMU is recognized by the University Grants Commission under Section 2(f) of the UGC Act, 1956 vide letter No F. 9-7/96(CPP-I) dated 9th Dec 1998 and approved by the Government of India. All courses run by the university are approved by the regulatory bodies like Medical Council of India (MCI), Nursing Council of India, Indian Association of Physiotherapy, All India Council for Technical Education (AICTE) and the Distance Education Council