The University's main Campus was initially located in a sprawling area of over 1000 acres in Palkalaiperur. However, as years passed on, the South Campus at Palkalaiperur with the available infrastructure was donated to the newly started Anna University of Technology. Very recently, another portion of the land has been allotted to the Indian Institute of Management (IIM), Tiruchirappalli. Also, the University has a downtown campus at Khajamalai, which housed originally the Autonomous Post-Graduate Centre of the University of Madras at Tiruchirappalli..